Botulinum Toxin Resistance: Causes, Symptoms, and Solutions

When you search the list of the most trending cosmetic injectables to rejuvenate the skin, then Botox will definitely appear among the top. It is an ideal solution to those people who wish to avoid dynamic wrinkles that are normally caused by the movement of the active parts of the face. The botulinum toxin type A works as follows, once the injection is done in the muscle, the solution must trickle to the nerve ending of the target muscle to numb it and prevent the contracting. In this way, an individual will acquire a more relaxed look over a period of time (an average of three months or four months, depending on a case to case basis). But what should one do in case someone exhibits the sign of resistance to botulinum toxin? What can we do to make it a calm and successful experience at the clinic and reach the desired outcomes without thinking about invasive interventions? We are about to highlight everything of importance with regards to Botox resistance in the ensuing article, thus, we are going to get into the discussion together!

Definition of Botox resistance

Botox resistance is the situation that shows that a patient has the neutralizing antibodies that do not enable botulinum neurotoxin to show its effect correctly or that their bodies eliminate Botox too quickly, and it is unable to show appropriate results. Consequently, patients fail to achieve the wanted look, or the effect is too rapid that past therapies are purely a waste of cash. The problem is very uncommon: experts state that true Botox-neutralizing antibodies in the immune system only 1 per 10.000 patients may develop. But, the reasons of botulinum toxin type A resistance are otherwise, therefore, we better take a glimpse at them too to realise the subject in more detail.

As an aesthetic practitioner, you need to realize the significance of top quality Botox that you can employ in your clinic. It also helps to dictate the successfulness of the treatment and the well-being of your patients, thus do not underrate the reliability of your supplier. Purchase botulinum toxin products by a reliable company so that your experience in your clinic could be unique and positive.

What Causes Botox Resistance?

The reason why Botox injection fails to work is not just being botulinum toxin resistant. Listed below will be some of the other issues that may influence the manner in which a person reacts to the treatment:

Frequently-repeated injections. Majority of patients that develop an immune response to botox simply overuse the solution, thus the body begins to produce so-called neutralizing antibodies, which fail to give the botulinum toxin a chance to act sufficiently;

The treatment involves overuse of Botox. Medical testings have revealed that repeated Botox use may cause botulinum neurotoxin type A immunity when used in excess by an individual person. In order not to face this problem, fewer doses of the solution as well as the diminishing of the injections are preferable;

The addition of accessory non toxic proteins. The majority of products available on the market based on Botulinum toxin which are applied in clinical practice have other proteins added to enhance the stability of the solution. But here a Nobel exception should be noted Xeomin. Such a brand also undergoes a special process of purification in order to eliminate all the useless proteins of its composition, leaving only active neuromodulators;

Poor conditions of storing the product. Botox should continue to be in the refrigerator set by the recommended temperature by Allergan, otherwise it may spoil and become ineffective;

Poor injection method in the process of treatment. Every individual is an individual and in such a way, the approach methodology should be selected in accordance with the needs of a certain patient as well as their aesthetic wishes, peculiarities of skin and body and some other key factors. When specialist attempts to use a single technique to treat all people- they are likely to fail.

Contaminationism neurotoxin in the product. The professionals have to administer high-quality injections to guarantee safe treatment to their patients. When Botox is purchased online at a company of unknown origin, and that particular organization deals with fake drugs and medicines then things can end up being worse than they are intended to be.

Prior to the injection, a patient should speak through all the peculiarities of the treatment with a specialist to take into account all the risks, negative outcomes, expectations, and other conveniences that are indispensable to a favorable experience in the office of a doctor. And this is how one can customize a plan of treatment to his/her demands and current states.

The key Symptoms of Botox Resistance

The most crucial point that you are to keep in mind in case you attempt to interpret whether a patient experiences Botox resistance is that time will assist you in comprehending all the symptoms. Since any product containing botulinum toxin takes one week or two to exhibit maximum improvement, it might not be a simple task to outline Botox resistance at that given time. But when there are still no signs of improvement after 4 weeks, or when there is mere improvement, then one can have the likelihood of a person reacting wrongly to his or her treatment. Here, an individual is supposed to reach out to a physician as soon as possible and make them aware of his or her suspicions.

The nerve endings will not be able to react normally in ordinary situations and hence minimizing the wrinkles when any part of the face is drawn in motion. In the event that four weeks since the administration session has gone by and there is no progression of the signs, the possibilities are high that it is Botox resistance.

What to Do in a Case when Botox Does Not Work in a Person?

A person can do the following things in case s/he is Botox resistant:

Discuss a course of treatment with a doctor. It is not uncommon that increased dose would be the right answer, so make another appointment to intensify the effect of Botox;

Use the services of a different healthcare provider. In some cases, the methods used by a doc might be different and thus perhaps even the specialist you consulted turns out not to be suiting you. Ask your doctor to turn to another specialist to make a second opinion in your case;

Take a different method of treatment. There exist other brief cosmetic treatments which can give a lengthier impact than Botox. Dermal fillers, mesotherapy, thread lifting, and many others will be an ideal solution to the problem of facial rejuvenation and must be certainly taken into consideration as an alternative.

What To Do Overcome Botox Resistance?

To overcome Botox resistance, the finest solution would be to take an alternative type of botulinum toxin (such as Xeomin) and a long break prior to administrating Botox again. In case you would like to change to Xeomin, keep in mind that the duration of the effect of this injectable can be up to six months, you are to wait about two weeks to notice the improvement, and the maintenance treatment should occur not less than every eight months.

Otherwise, one can mention other kinds of a treatment which can be taken as an alternative to therapeutic protein products: dermal fillers, mesotherapy solution, PDO threads, and many more on the market. You just have to find a supplier who has good quality products and that is the most important thing in Botox treatment.

Conclusion

The resistance to botulinum toxin is not a widespread case, and that is why it is not talked about so much amongst the human population. Behind this problem, there can be several causes, yet the primary one is the excessive usage of this solution that is most frequently enough to make the body develop botulinum toxin-neutralizing antibodies that fail to allow Botox to act adequately. In case it occurs, patients might think of one of the following: to wait at least half a year to attempt to apply Botox once more or replace it with Xeomin which contains fewer ingredients and is not very likely to cause an equally accurate response in the body. Naturally, it is possible to always experiment with some other aesthetic procedures since there are numerous aesthetic procedures on the market. That is all in today discussion. I hope that you have gotten answers to all the questions here.