In this post, Modern Aminos reviews SLU-PP-332 and Phenibut HCL. These are top-tier research chemicals designed for licensed laboratories and scientific professionals. Licensed researchers require consistent compound performance for reproducible results. Consistency ensures reliable data and robust scientific conclusions. Therefore, selecting high‑quality reagents is critical for experimental success. Modern Aminos specializes in providing such high‑grade compounds to global research labs.
What is SLU‑PP‑332?
SLU‑PP‑332 is a synthetic small molecule and potent non‑selective estrogen‑related receptor agonist. It most strongly activates ERRα with an EC₅₀ of 98 nM. This activation increases energy expenditure, enhances fatty acid oxidation, and improves mitochondrial function. For researchers seeking SLU PP 332 for sale, Modern Aminos provides high-purity options.
Chemistry and Mechanism
SLU‑PP‑332 has formula C₁₈H₁₄N₂O₂ and molar mass 290.32 g/mol. Researchers synthesized it via esterification followed by hydrazide condensation. It binds the ERR ligand domain, upregulating PGC‑1α and oxidative phosphorylation genes.
Research Applications
SLU‑PP‑332 boosts fat oxidation and lipolysis without affecting appetite or exercise motivation. It reduces visceral fat, improves insulin sensitivity, and protects kidneys. In metabolic syndrome models, SLU‑PP‑332 lowered blood glucose and triglyceride levels. This preclinical efficacy highlights its potential in metabolic disease research. SLU‑PP‑332 improved heart function and reduced fibrosis in preclinical models. Researchers observe enhanced mitochondrial density and reduced scarring in animal hearts. Treated mice ran 45 % further and 70 % longer on a treadmill assay.
Dosage Recommendations
Early studies use 200–400 mcg daily split into two doses. SLU‑PP‑332’s half‑life is about 1.5 hours. Researchers recommend initiating at low concentrations and titrating based on assay response. Adhering to cyclic dosing may prevent receptor downregulation and maintain efficacy.
Safety and Handling
Animal trials show minimal side effects at standard dosages. Use protective gloves, goggles, and lab coats when handling SLU‑PP‑332. Moreover, store aliquots desiccated at −20 °C to maintain compound integrity.
Demystifying Phenibut HCL
Phenibut HCl is a white crystalline compound categorized as a GABA‑B receptor agonist. First synthesized and introduced in the Soviet Union during the 1960s, it was used clinically to manage anxiety and improve cognitive performance under stress. In modern research, Phenibut HCL for sale through Modern Aminos represents a lab-only, high-purity standard for neurochemical research models. Its selective receptor affinity and ability to cross the blood-brain barrier make it particularly appealing for studying neurological functions.
Chemical Profile and Mechanism
Phenibut HCl carries the molecular formula C₁₀H₁₄ClNO₂ with a molar mass of 215.67 g/mol. As a structural analog of GABA (γ‑aminobutyric acid), Phenibut incorporates a phenyl ring that increases lipophilicity, enhancing its capacity to cross the blood‑brain barrier. Once in the CNS, it binds to GABA‑B receptors and inhibits excitatory neurotransmitter release. This modulation helps attenuate overstimulation in stress-related circuits and provides measurable behavioral effects in animal models. For deeper analysis, see its profile on PubChem and cross-reference with the comprehensive receptor database on DrugBank.
Recommended Lab Protocols
For reproducibility, Phenibut HCl should be stored at ambient room temperature (20–25°C) in a desiccated environment. Light-sensitive containers are advised to minimize degradation. To prepare experimental solutions, dissolve Phenibut HCl in sterile deionized water or DMSO. Typical research concentrations range from 10 mm to 50 mm, depending on receptor binding study, synaptosomal prep, or PK profiling. Always filter-sterilize solutions prior to use in in vitro models to avoid contamination.
In behavioral models, intraperitoneal or oral gavage routes can be used under standardized laboratory protocols. Phenibut’s onset time and CNS penetration kinetics allow time-course analyses within a 30-minute to 2-hour window.
Handling and Storage
Lab technicians and scientists should employ full PPE, including nitrile gloves, protective goggles, and face masks when handling Phenibut HCl. Because of its CNS-active profile, all manipulations should occur inside a certified chemical fume hood. Label and date all sample aliquots clearly, and track compound usage and lot integrity through your laboratory information management system (LIMS). Maintain clear separation from compounds used in human-related trials to ensure regulatory compliance.
Key Benefits of SLU‑PP‑332 and Phenibut HCL
Metabolic Pathway Analysis
SLU‑PP‑332 helps map fatty acid oxidation and mitochondrial biogenesis pathways. This makes it ideal for studies on energy metabolism and thermogenesis.
Neurochemical Studies
Phenibut HCl serves as a robust investigative tool for GABA‑B receptor modulation. This compound enables researchers to dissect the roles of GABAergic transmission in anxiety, cognition, and synaptic plasticity. It offers a specific yet flexible profile, making it ideal for electrophysiological experiments, calcium imaging, and synaptosomal preparations. Pairing it with patch-clamp electrophysiology allows deep analysis of inhibitory postsynaptic currents, particularly in limbic and cortical models.
Pharmacokinetic Profiling
With a half-life of approximately 5.3 hours, Phenibut HCl enables accurate construction of pharmacokinetic (PK) curves using modern analytical techniques like LC‑MS and HPLC-UV. Labs can map bioavailability, absorption, and elimination curves in plasma and CNS tissue. In advanced models, dual-labeling assays can determine compound stability across metabolic compartments, offering insight into both systemic and localized effects over time.
Renal and Hepatic Studies
SLU‑PP‑332 demonstrates strong nephroprotective effects, notably through its reduction of albuminuria and oxidative stress markers in senescence-accelerated models. In hepatic tissue studies, it aids lipid clearance and mitigates steatosis by activating ERRα pathways and reducing inflammatory gene expression. These outcomes make it invaluable in researching therapies for chronic kidney disease and non-alcoholic fatty liver disease (NAFLD).
Custom Protocol Integration
SLU‑PP‑332 can be seamlessly integrated into metabolic and cardiovascular protocol arrays. Combine it with lipolysis and VO₂ assays to evaluate its exercise-mimetic properties, such as oxygen uptake efficiency and endurance signaling. Meanwhile, Phenibut HCl supports neurotransmitter regulation assays like dopamine turnover, GABA reuptake inhibition, and evoked neurotransmission studies in microfluidic chamber systems. These integrations broaden research applications and enable compound comparison studies.
Maximizing Research Outcomes: Actionable Tips
- Verify compound purity using HPLC or LC‑MS before initiating experiments.
- Cycle SLU‑PP‑332 use with off-weeks to prevent receptor desensitization or signaling fatigue.
- Document all solvents, reagent grades, and batch numbers clearly in your lab notebook.
- Always use both negative and positive controls tailored to each experimental setup.
- Employ blinded randomization where applicable to reduce bias in behavioral assays.
- Include dose-response curves to identify the therapeutic index and tolerance thresholds.
Regulatory and Quality Considerations
These compounds are for research use only and not for consumption. Follow local regulations and institutional biosafety guidelines. Review batch‑specific COAs for each lot to ensure consistency. See relevant regulatory advice on NIH Database.
Conclusion
By leveraging SLU‑PP‑332 and Phenibut HCl, labs can unlock deeper insights into metabolism and neurochemistry. Modern Aminos remains committed to supplying quality research compounds for licensed professionals. For broader healthcare implications of research like this, visit Wild Lab Sky for related content on biotechnology and longevity.
